2025 Rx 350 Hybrid Mpg. The epa's data shows that the most efficient rx model is the rx350h, which carries claimed ratings of 37 mpg city and 34 mpg highway. A 350h model we tested was quiet and refined, but steering feel was lacking.

The motortrend buyer’s guide has the 2025 lexus rx hybrid specs you need, from dimensions and cargo space to power and mpgs. See detailed specs, features, packages and dimensions by trim level for the 2025 lexus rx 350.